Product Name:(2-Fluoro-6-isopropoxyphenyl)boronic acid
IUPAC Name:[2-fluoro-6-(propan-2-yloxy)phenyl]boronic acid
Product Overview |
2-Fluoro-6-isopropoxyphenylboronic acid (2FIPBA) is a boronic acid derivative, first synthesized in 1996 by W. J. Shieh and co-workers. It has been used in a variety of scientific research applications, including as a catalyst in organic synthesis, as a reagent in organometallic chemistry, and in the study of boron-containing compounds. |
Synthesis and Application |
2-Fluoro-6-isopropoxyphenylboronic acid can be synthesized via a three-step procedure starting from 4-fluoro-3-nitrobenzaldehyde. The first step involves the reaction of 4-fluoro-3-nitrobenzaldehyde with potassium hydroxide and sodium nitrite in ethanol to form 4-fluoro-3-nitrobenzyl alcohol. The second step involves the reaction of 4-fluoro-3-nitrobenzyl alcohol with isopropylmagnesium bromide in THF to form 2-fluoro-6-isopropoxyphenylboronic acid. The final step involves the reaction of 2-fluoro-6-isopropoxyphenylboronic acid with sodium borohydride in THF to form the desired product, 2-Fluoro-6-isopropoxyphenylboronic acid. 2-Fluoro-6-isopropoxyphenylboronic acid has been used in a variety of scientific research applications. It has been used as a catalyst in organic synthesis, as a reagent in organometallic chemistry, and in the study of boron-containing compounds. It has also been used in the synthesis of a variety of compounds, including pyridines, quinolines, and indoles. |
Future Directions |
There are several potential future directions for 2-Fluoro-6-isopropoxyphenylboronic acid. It could be used in the synthesis of novel boron-containing compounds, such as boron-doped semiconductors. It could also be used in the study of boron-containing enzymes and proteins. Additionally, it could be used in the study of boron-containing pharmaceuticals and in the development of new boron-containing drugs. Finally, it could be used in the study of boron-containing materials for use in energy storage and conversion. |