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PRODUCT CATALOGUE

PROTAC-E3 Ligase Ligands

Bifunctional degrader molecules, also called proteolysis-targeting chimeras (PROTACs), are a new modality of chemical tools and potential therapeutics to understand and treat human disease. A required PROTAC component is a ligand binding to an E3 ubiquitin ligase, which is then joined to another ligand binding to a protein to be degraded via the ubiquitin–proteasome system. The advent of nonpeptidic small-molecule E3 ligase ligands revolutionized the field and ushered in the design of drug-like PROTACs with potent and selective degradation activity.

3-(4-amino-1-oxoisoindolin-2-yl)piperidine-2,6-dione hemihydrate
3-(4-amino-1-oxoisoindolin-2-yl)piperidine-2,6-dione hemihydrate
CM133051
847871-99-2
3-[6-(aminomethyl)-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione
3-[6-(aminomethyl)-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione
CM327341
1010100-28-3
3-[7-(aminomethyl)-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione
3-[7-(aminomethyl)-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione
CM327918
790652-68-5
2-(2,6-dioxopiperidin-3-yl)-4-hydroxyisoindole-1,3-dione
2-(2,6-dioxopiperidin-3-yl)-4-hydroxyisoindole-1,3-dione
CM328451
5054-59-1
2-(2,6-Dioxopiperidin-3-yl)-5-hydroxyisoindoline-1,3-dione
2-(2,6-Dioxopiperidin-3-yl)-5-hydroxyisoindoline-1,3-dione
CM334083
64567-60-8
(2S,4R)-1-[(2S)-2-acetamido-3,3-dimethylbutanoyl]-4-hydroxy-N-[[4-(4-methyl-1,3-thiazol-5-yl)phenyl]methyl]pyrrolidine-2-carboxamide
(2S,4R)-1-[(2S)-2-acetamido-3,3-dimethylbutanoyl]-4-hydroxy-N-[[4-(4-methyl-1,3-thiazol-5-yl)phenyl]methyl]pyrrolidine-2-carboxamide
CM338813
1448188-62-2
3-(6-bromo-3-oxo-1H-isoindol-2-yl)piperidine-2,6-dione
3-(6-bromo-3-oxo-1H-isoindol-2-yl)piperidine-2,6-dione
CM338814
1010100-26-1
3-(7-hydroxy-3-oxo-1H-isoindol-2-yl)piperidine-2,6-dione
3-(7-hydroxy-3-oxo-1H-isoindol-2-yl)piperidine-2,6-dione
CM338815
1061604-41-8
2-(2,6-dioxopiperidin-3-yl)-4-fluoroisoindole-1,3-dione
2-(2,6-dioxopiperidin-3-yl)-4-fluoroisoindole-1,3-dione
CM338816
835616-60-9
2-(2,6-dioxopiperidin-3-yl)-5-fluoroisoindole-1,3-dione
2-(2,6-dioxopiperidin-3-yl)-5-fluoroisoindole-1,3-dione
CM338817
835616-61-0
2-(2,6-dioxopiperidin-3-yl)-4-prop-2-ynoxyisoindole-1,3-dione
2-(2,6-dioxopiperidin-3-yl)-4-prop-2-ynoxyisoindole-1,3-dione
CM338818
2098487-39-7
3-(6-hydroxy-3-oxo-1H-isoindol-2-yl)piperidine-2,6-dione
3-(6-hydroxy-3-oxo-1H-isoindol-2-yl)piperidine-2,6-dione
CM338819
1416990-08-3
2,6-Piperidinedione, 3-(6-fluoro-1,3-dihydro-1-oxo-2H-isoindol-2-yl)-
2,6-Piperidinedione, 3-(6-fluoro-1,3-dihydro-1-oxo-2H-isoindol-2-yl)-
CM338820
2468780-87-0
3-[6-(aminomethyl)-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione;hydrochloride
3-[6-(aminomethyl)-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione;hydrochloride
CM350889
1158264-69-7
(2S,4R)-1-[(2S)-3,3-dimethyl-2-[(2-prop-2-ynoxyacetyl)amino]butanoyl]-4-hydroxy-N-[[4-(4-methyl-1,3-thiazol-5-yl)phenyl]methyl]pyrrolidine-2-carboxamide
(2S,4R)-1-[(2S)-3,3-dimethyl-2-[(2-prop-2-ynoxyacetyl)amino]butanoyl]-4-hydroxy-N-[[4-(4-methyl-1,3-thiazol-5-yl)phenyl]methyl]pyrrolidine-2-carboxamide
CM340798
2098799-78-9
L-Leucine, N-[(2S,3R)-3-[[(9H-fluoren-9-ylmethoxy)carbonyl]amino]-2-hydroxy-1-oxo-4-phenylbutyl]-
L-Leucine, N-[(2S,3R)-3-[[(9H-fluoren-9-ylmethoxy)carbonyl]amino]-2-hydroxy-1-oxo-4-phenylbutyl]-
CM340799
1225383-33-4
Acetic acid, 2-[[1-(2-chloroacetyl)-1,2,3,4-tetrahydro-6-quinolinyl]oxy]-
Acetic acid, 2-[[1-(2-chloroacetyl)-1,2,3,4-tetrahydro-6-quinolinyl]oxy]-
CM340800
2375196-30-6
Nonanoic acid, 9-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]oxy]-, 1,1-dimethylethyl ester
Nonanoic acid, 9-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]oxy]-, 1,1-dimethylethyl ester
CM340801
2225148-52-5
3-(7-amino-3-oxo-1H-isoindol-2-yl)piperidine-2,6-dione;hydrochloride
3-(7-amino-3-oxo-1H-isoindol-2-yl)piperidine-2,6-dione;hydrochloride
CM340802
1243329-97-6
Acetaldehyde, 2-[2-[2-[2-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]amino]ethoxy]ethoxy]ethoxy]-
Acetaldehyde, 2-[2-[2-[2-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]amino]ethoxy]ethoxy]ethoxy]-
CM340803
2360530-43-2
2-[4-[(4R,5S)-4,5-bis(4-chlorophenyl)-2-(4-methoxy-2-propan-2-yloxyphenyl)-4,5-dihydroimidazole-1-carbonyl]-2-oxopiperazin-1-yl]acetic acid
2-[4-[(4R,5S)-4,5-bis(4-chlorophenyl)-2-(4-methoxy-2-propan-2-yloxyphenyl)-4,5-dihydroimidazole-1-carbonyl]-2-oxopiperazin-1-yl]acetic acid
CM340805
2306390-08-7
(2S)-2-[[(2S,3R)-2-hydroxy-3-[(2-methylpropan-2-yl)oxycarbonylamino]-4-phenylbutanoyl]amino]-4-methylpentanoic acid
(2S)-2-[[(2S,3R)-2-hydroxy-3-[(2-methylpropan-2-yl)oxycarbonylamino]-4-phenylbutanoyl]amino]-4-methylpentanoic acid
CM340806
87304-15-2
4,5,6,7-tetradeuterio-2-(2,6-dioxopiperidin-3-yl)isoindole-1,3-dione
4,5,6,7-tetradeuterio-2-(2,6-dioxopiperidin-3-yl)isoindole-1,3-dione
CM340807
1219177-18-0
3-[7-(aminomethyl)-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione;hydrochloride
3-[7-(aminomethyl)-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione;hydrochloride
CM340808
444289-05-8