Product Name:8-chloro-4-(dimethylaminomethylene)-1-(2-fluoro-6-methoxy-phenyl)-3H-2-benzazepin-5-one

IUPAC Name:8-chloro-4-[(dimethylamino)methylidene]-1-(2-fluoro-6-methoxyphenyl)-4,5-dihydro-3H-2-benzazepin-5-one

CAS:869367-33-9
Molecular Formula:C20H18ClFN2O2
Purity:95%+
Catalog Number:CM1018162
Molecular Weight:372.82

Packing Unit Available Stock Price($) Quantity
CM1018162-100mg in stock ȅŞǫ
CM1018162-250mg in stock ǫƚƚ
CM1018162-500mg 1-2 Weeks ƐƚƚƐ
CM1018162-1g 1-2 Weeks ƐŪƚƚ
CM1018162-5g 1-2 Weeks ȖŪƚƚ

For R&D use only.

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Product Details

CAS NO:869367-33-9
Molecular Formula:C20H18ClFN2O2
Melting Point:-
Smiles Code:COC1=CC=CC(F)=C1C1=NCC(=CN(C)C)C(=O)C2=CC=C(Cl)C=C12
Density:
Catalog Number:CM1018162
Molecular Weight:372.82
Boiling Point:
MDL No:
Storage:

Column Infos

Alisertib
Puma Biotechnology announced the initiation of its ALISertib in CAncer (ALISCA-Lung1) Phase II trial of alisertib monotherapy for the treatment of patients with extensive stage small cell lung cancer. The ALISCA-Lung1 trial will enroll up to 60 patients with extensive stage small cell lung cancer who have progressed on or after first-line platinum-based chemotherapy and immunotherapy. The primary endpoint of the trial is objective response rate, with secondary endpoints of duration of response, disease control rate, progression-free survival and overall survival. Based upon the outcomes of the study, Puma anticipates meeting with the FDA to explore the potential for an accelerated approval pathway for alisertib in small cell lung cancer. Alisertib is an orally active and selective Aurora A kinase inhibitor, which binds to Aurora A kinase resulting in mitotic spindle abnormalities, mitotic accumulation.
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