Product Name:Ald-Ph-NHS ester

IUPAC Name:2,5-dioxopyrrolidin-1-yl 4-formylbenzoate

CAS:60444-78-2
Molecular Formula:C12H9NO5
Purity:95%+
Catalog Number:CM123273
Molecular Weight:247.21

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Product Details

CAS NO:60444-78-2
Molecular Formula:C12H9NO5
Melting Point:-
Smiles Code:O=C(ON1C(CCC1=O)=O)C2=CC=C(C=O)C=C2
Density:
Catalog Number:CM123273
Molecular Weight:247.21
Boiling Point:425.4°C at 760 mmHg
MDL No:MFCD00133733
Storage:Keep in inert atmosphere, store in freezer, under -20°C.

Category Infos

ADC-Linkers
The ADC linker is one of the three main components of antibody drug conjugates (ADCs), linking the antibody to the effective drug (payload) through chemical bonds. ADC linkers play a key role in determining the overall success of antibody drug conjugates. One of the major challenges in developing safe and effective ADC drugs is to assemble an ideal chemical linker between the cytotoxic payload and the mAb. Well-designed ADC linkers can help the selective delivery of antibodies at the tumor site and the accurate release of cytotoxic drugs.
N-Hydroxysuccinimide (NHS)
N-Hydroxysuccinimide
Non-cleavable linkers
Noncleavable linkers consist of stable bonds that resist proteolytic degradation and provide higher stability than the cleavable linkers.
Hydrazones/Aldehydes/Ketones
A hydrazine or hydrazide group is able to react with an aldehyde or ketone to form a dehydration product, called a hydrazone.

Column Infos

Pyrroles
Pyrrole is a five membered heterocyclic compound with the molecular formula of C4H5N. Pyrrole has a ring composed of four carbon atoms and one nitrogen atom. Pyrrole is easy to polymerize in the air. Pyrrole is the parent compound of many important biological substances (such as bile pigment, porphyrin and chlorophyll). Pyrrole scaffolds are widely used in biological and pharmaceutical fields. Pyrrole is a special heterocyclic scaffold, which exists in many natural products, drug molecules and pesticides, and has shown its application in materials science.
Benzenes
Benzene is an important organic compound with the chemical formula C6H6, and its molecule consists of a ring of 6 carbon atoms, each with 1 hydrogen atom. Benzene is a sweet, flammable, colorless and transparent liquid with carcinogenic toxicity at room temperature, and has a strong aromatic odor. It is insoluble in water, easily soluble in organic solvents, and can also be used as an organic solvent itself. The ring system of benzene is called benzene ring, and the structure after removing one hydrogen atom from the benzene ring is called phenyl. Benzene is one of the most important basic organic chemical raw materials. Many important chemical intermediates can be derived from benzene through substitution reaction, addition reaction and benzene ring cleavage reaction.

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