cas 499195-60-7|| where to buy ethyl 4-(2-chloropyrimidin-4-yl)benzoate

Product Name:ethyl 4-(2-chloropyrimidin-4-yl)benzoate

IUPAC Name:ethyl 4-(2-chloropyrimidin-4-yl)benzoate

: CAS：499195-60-7; Molecular Formula：C13H11ClN2O2; Purity：95%+

: Catalog Number：CM159842; Molecular Weight：262.69

Packing Unit	Available Stock	Price($)
CM159842-1g	in stock	ƀȁ
CM159842-5g	in stock	ưȬŴ

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Product Details

: CAS NO:499195-60-7; Molecular Formula:C13H11ClN2O2; Melting Point:-; Smiles Code:O=C(OCC)C1=CC=C(C2=NC(Cl)=NC=C2)C=C1; Density:

: Catalog Number:CM159842; Molecular Weight:262.69; Boiling Point:; MDL No:; Storage:Store at 2-8°C.

Category Infos

: Pyrimidines; Pyrimidine, also known as 1,3-diazobenzene, is a heterocyclic compound with the chemical formula C4H4N2. Pyrimidine is formed by substituting 2 nitrogen atoms for 2 carbons in the meta-position of benzene. It is a diazine and retains its aromaticity. Derivatives of pyrimidine widely exist in organic macromolecular nucleic acids, and many drugs also contain pyrimidine rings. In nucleic acids, three nucleobases are pyrimidine derivatives: cytosine, thymine and uracil. There are a variety of pyrimidine-containing drugs on the market, most of which are kinase inhibitors.

: Benzenes; Benzene is an important organic compound with the chemical formula C6H6, and its molecule consists of a ring of 6 carbon atoms, each with 1 hydrogen atom. Benzene is a sweet, flammable, colorless and transparent liquid with carcinogenic toxicity at room temperature, and has a strong aromatic odor. It is insoluble in water, easily soluble in organic solvents, and can also be used as an organic solvent itself. The ring system of benzene is called benzene ring, and the structure after removing one hydrogen atom from the benzene ring is called phenyl. Benzene is one of the most important basic organic chemical raw materials. Many important chemical intermediates can be derived from benzene through substitution reaction, addition reaction and benzene ring cleavage reaction.

Column Infos

: Benzenes

: Momelotinib; GSK’s novel small molecule drug, Momelotinib (Ojjaara) has been approved by the U.S. FDA on September 15 for the treatment of intermediate or high-risk myelofibrosis, including primary myelofibrosis or secondary myelofibrosis (post-polycythaemia vera and post-essential thrombocythaemia), in adults with anaemia.
Myelofibrosis is a rare and fatal form of bone marrow cancer, often resulting in anemia, constitutional symptoms such as fatigue, night sweats, and bone pain, and splenomegaly. These key manifestations of myelofibrosis, including anaemia, have limited treatment options and causing over 30% patients discontinuing treatment.
Momelotinib fills a significant unmet medical need, and has a potential of being a standard-of-care treatment for newly diagnosed and previously treated patients with anaemia. Under a unique mechanism of action, Momelotinib, inhibits Janus kinase (JAK) 1, JAK2, and activin A receptor, type I (ACVR1) along three key signalling pathways. The phase III study has demonstrated clinical activity against anemia, constitutional symptoms, and splenomegaly.

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