cas 42754-96-1|| where to buy 4,6-dichloro-1H-pyrazolo[3,4-d]pyrimidine

Product Name:4,6-dichloro-1H-pyrazolo[3,4-d]pyrimidine

IUPAC Name:4,6-dichloro-1H-pyrazolo[3,4-d]pyrimidine

Packing Unit	Available Stock	Price($)
CM104106-5g	in stock	ǵǤ
CM104106-25g	in stock	ůŗŗ
CM104106-100g	in stock	Ǌůŗ

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: CAS NO:42754-96-1; Molecular Formula:C5H2Cl2N4; Melting Point:-; Smiles Code:ClC1=NC(Cl)=C2C=NNC2=N1; Density:

: Catalog Number:CM104106; Molecular Weight:189; Boiling Point:; MDL No:MFCD09835493; Storage:Keep in inert atmosphere, store at 2-8°C.

: Pyrazolopyrimidines; Pyrazolopyrimidine scaffolds are one of the most important heterocyclic compounds in drug discovery. This scaffold has various biological activities, among which anticancer is an important one.

: ORIC-533; ORIC-533 is a potential best-in-class, oral inhibitor of CD73 developed by ORIC Pharmaceuticals which is currently in a Ph. Ib trial for the treatment of relapsed/refractory multiple myeloma (MM). It inhibits the CD73-mediated conversion of AMP to adenosine which generates an immunosuppressive tumor microenvironment and has the potential to be a next-generation immunotherapy. The in-depth use of co-crystal structures led the team to discover a novel set of phosphonate bioisosteres which were able to achieve bioavailability for a highly polar scaffold. The structure and discovery story of ORIC-533 were recently presented at the ACS Spring 2024 Meeting in New Orleans.
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