Product Name:4,6-dichloro-1H-pyrazolo[3,4-d]pyrimidine

IUPAC Name:4,6-dichloro-1H-pyrazolo[3,4-d]pyrimidine

CAS:42754-96-1
Molecular Formula:C5H2Cl2N4
Purity:95%+
Catalog Number:CM104106
Molecular Weight:189

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Product Details

CAS NO:42754-96-1
Molecular Formula:C5H2Cl2N4
Melting Point:-
Smiles Code:ClC1=NC(Cl)=C2C=NNC2=N1
Density:
Catalog Number:CM104106
Molecular Weight:189
Boiling Point:
MDL No:MFCD09835493
Storage:Keep in inert atmosphere, store at 2-8°C.

Category Infos

Pyrazolopyrimidines
Pyrazolopyrimidine scaffolds are one of the most important heterocyclic compounds in drug discovery. This scaffold has various biological activities, among which anticancer is an important one.

Column Infos

ORIC-533
ORIC-533 is a potential best-in-class, oral inhibitor of CD73 developed by ORIC Pharmaceuticals which is currently in a Ph. Ib trial for the treatment of relapsed/refractory multiple myeloma (MM). It inhibits the CD73-mediated conversion of AMP to adenosine which generates an immunosuppressive tumor microenvironment and has the potential to be a next-generation immunotherapy. The in-depth use of co-crystal structures led the team to discover a novel set of phosphonate bioisosteres which were able to achieve bioavailability for a highly polar scaffold. The structure and discovery story of ORIC-533 were recently presented at the ACS Spring 2024 Meeting in New Orleans.
Chemenu has been working to develop more compounds for drug discovery. Here are the building blocks we can provide.