cas 287729-03-7|| where to buy tert-butyl allyl(1,3-dioxoisoindolin-2-yl)carbamate

Product Name:tert-butyl allyl(1,3-dioxoisoindolin-2-yl)carbamate

IUPAC Name:N-(1,3-dioxo-2,3-dihydro-1H-isoindol-2-yl)-N-(prop-2-en-1-yl)(tert-butoxy)formamide

: CAS：287729-03-7; Molecular Formula：C16H18N2O4; Purity：95%

: Catalog Number：CM263007; Molecular Weight：302.33

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Product Details

: CAS NO:287729-03-7; Molecular Formula:C16H18N2O4; Melting Point:-; Smiles Code:O=C(OC(C)(C)C)N(CC=C)N(C(C1=C2C=CC=C1)=O)C2=O; Density:

: Catalog Number:CM263007; Molecular Weight:302.33; Boiling Point:; MDL No:; Storage:

Category Infos

: Isoindolinediones

Column Infos

: Wee1 inhibitors; Wee1 protein is the most well-known Wee protein, and Wee1 protein kinases are members of the serine/threonine family and are highly conserved in evolution and are abundantly present in many eukaryotes and are very active in the S and G2 phases of the cell cycle. Wee1 protein kinase is a key regulatory center in DNA replication, chromosomal concentration, and histone transcription. These biological behavioral abnormalities can lead to genomic instability and cause malignant tumors, but inhibition or down-regulation of Wee1 protein kinase expression in malignant tumors can trigger mitotic catastrophe and apoptosis leads to tumor cell death. It has now been found that the expression of Wee1 is up-regulated in many cancers, and it has been clinically found that treatment with an inhibitor of Wee1 can effectively improve the occurrence and development of cancer. At present, many companies have deployed this target, and some have progressed to the clinical stage. Some Wee1 inhibitors under development include Adavosertib(ADZ1775), Azenosertib, ZNL-06-096, Debio-0123 and SGR-3515.
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