Product Name:tert-butyl 4-(1-methoxy-1,3-dioxopentan-2-yl)piperazine-1-carboxylate

IUPAC Name:tert-butyl 4-(1-methoxy-1,3-dioxopentan-2-yl)piperazine-1-carboxylate

CAS:2869955-99-5
Molecular Formula:C15H26N2O5
Purity:95%+
Catalog Number:CM1078120
Molecular Weight:314.38

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Product Details

CAS NO:2869955-99-5
Molecular Formula:C15H26N2O5
Melting Point:-
Smiles Code:O=C(OC(C)(C)C)N1CCN(CC1)C(C(=O)OC)C(=O)CC
Density:1.130±0.06 g/cm3
Catalog Number:CM1078120
Molecular Weight:314.38
Boiling Point:397.8±42.0 °C
MDL No:
Storage:

Category Infos

Piperazines
Piperazine is an organic compound consisting of a six-membered ring containing two nitrogen atoms in opposite positions in the ring. The chemical formula of piperazine is C4H10N2, and it is an important pharmaceutical intermediate. Pyrimidines and piperazines are known to be the backbone of many bulk compounds and important core structures for approved drugs; studies have shown that combining a pyridine ring with a piperazine moiety within a single structural framework enhances biological activity.

Column Infos

HRO761
Novartis'HRO761 is an oral allosteric inhibitor targeting WRN helicase, aimed at treating microsatellite instability (MSI) or deficient mismatch repair (dMMR) tumors. WRN has emerged as a critical synthetic lethal target in MSI cancers, which are common in colorectal, gastric, endometrial, and ovarian cancers. Although MSI cancers show a high response rate to immune checkpoint inhibitors, many patients develop resistance. By acting on WRN, HRO761 may be able to stop the growth of the cancer.
Chemenu has been working to develop more compounds for drug discovery. Here are the building blocks we can provide.

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