cas 2763157-90-8|| where to buy 5,7-dichloro-8-fluoro-2-(methylsulfanyl)-3H,4H-pyrido[4,3-d]pyrimidin-4-one

Product Name:5,7-dichloro-8-fluoro-2-(methylsulfanyl)-3H,4H-pyrido[4,3-d]pyrimidin-4-one

IUPAC Name:5,7-dichloro-8-fluoro-2-(methylsulfanyl)-3H,4H-pyrido[4,3-d]pyrimidin-4-one

: CAS：2763157-90-8; Molecular Formula：C8H4Cl2FN3OS; Purity：95%+

: Catalog Number：CM1043992; Molecular Weight：280.1

Packing Unit	Available Stock	Price($)
CM1043992-100mg	in stock	ǊŉȎ
CM1043992-250mg	in stock	ǊƄƞ
CM1043992-1g	in stock	ȎưĽ
CM1043992-5g	in stock	ǊŉĽĽ

Inquiry: sales@chemenu.com

For R&D use only.

Inquiry Form

Chemical Name

CAS Number

Quantity*

Required Specifications*
(Assay %, Material Grade etc.)

Contact Name*

Contact Email*

Meanwhile I'd like to create a registered account on CHEMENU.COM with the above email.

I'd like to receive emails related to products with similar structures to 2763157-90-8 regularly via the above email.

Additional Notes

Verification code*

refresh

Product Details

: CAS NO:2763157-90-8; Molecular Formula:C8H4Cl2FN3OS; Melting Point:-; Smiles Code:CSC1=NC2=C(C(=O)N1)C(=NC(=C2F)Cl)Cl; Density:

: Catalog Number:CM1043992; Molecular Weight:280.1; Boiling Point:; MDL No:; Storage:

Category Infos

: Pyridopyrimidines

Column Infos

: HRS-4642; HRS-4642 is a high affinity, selective, long-acting, and non-covalent KRAS G12D inhibitor, with an affinity constant of 0.083 nM. HRS-4642 demonstrated robust efficacy against KRAS G12D-mutant cancers both in vitro and in vivo. Importantly, in a phase 1 clinical trial, HRS-4642 exhibited promising anti-tumor activity in the escalating dosing cohorts. Furthermore, the sensitization and resistance spectrum for HRS-4642 was deciphered through genome-wide CRISPR-Cas9 screening, which unveiled proteasome as a sensitization target. HRS-4642, either as a single agent or in combination with carfilzomib, reshaped the tumor microenvironment toward an immune-permissive one.

Related Products

916420-27-4

211244-81-4

126728-20-9

155690-79-2

573675-31-7

846036-77-9

938443-20-0

1013916-37-4

1016636-76-2

1053656-57-7

1056934-87-2

1059735-34-0

1092352-55-0

1172808-59-1

1196156-15-6

1215787-31-7

135481-57-1

157327-49-6

171178-33-9

39551-54-7

552331-44-9

635698-56-5

778574-06-4

849903-79-3

850628-76-1

914612-23-0

917748-53-9

1423034-11-0

259809-79-5

1370411-44-1

62458-96-2

635698-30-5

192869-80-0

1187830-71-2

1187830-76-7

1187830-79-0

62458-92-8

300552-47-0

573675-29-3

1313712-15-0

171178-47-5

210538-73-1

1187830-77-8

1171334-07-8

1208901-69-2

878743-46-5

1170023-46-7

1255099-37-6

1009821-06-0

351002-16-9

663619-91-8

1227958-02-2

1227958-17-9

1009303-44-9

938443-21-1

1227958-54-4

1439818-90-2

1083181-71-8

109229-22-3

1196154-90-1

1211594-56-7

1246471-35-1

1286330-15-1

1223748-53-5

1395493-36-3

1395493-14-7

1395492-92-8

1395493-24-9

159660-86-3

1395493-29-4

1395493-06-7

157327-50-9

23536-76-7

517895-69-1

55149-36-5

647863-02-3

647863-01-2

663619-90-7

705291-54-9

705292-04-2

726697-13-8

763925-38-8

849727-63-5

859825-79-9

859826-11-2

87591-79-5

882670-89-5

882670-90-8

256238-90-1

267243-49-2

300552-41-4

300552-48-1

32092-18-5

338739-98-3

352328-87-1

442531-33-1

52833-43-9

570415-48-4

1029720-75-9

1237537-34-6

1228666-56-5

1346808-81-8

1029-52-3

76807-54-0

869198-95-8

869296-21-9

1029420-94-7

1036738-12-1

126728-21-0

1314723-39-1

1332586-91-0

1375064-63-3

1449117-31-0

145733-62-6

1449117-45-6

152941-69-0

1637671-24-9

162469-87-6

16867-35-9

16867-56-4

175357-95-6

17326-27-1

210538-72-0

1160915-55-8

192869-49-1

938443-19-7

1000578-08-4

1092352-58-3

1187830-52-9

1187830-54-1

1187830-78-9

1187830-72-3

1187830-73-4

1226776-81-3

1172930-59-4

908240-50-6

41078-70-0

63234-80-0

1008796-22-2

69981-00-6

130049-82-0

1000386-01-5

80360-06-1

949654-76-6

91996-76-8

918898-11-0

1053656-41-9

1073440-84-2

1080644-24-1

1098588-16-9

1160248-14-5

1174007-81-8

1174007-44-3

1201781-22-7

120040-42-8

1211516-37-8

1209597-83-0

1220039-65-5

1255574-50-5

1261171-00-9

1260761-86-1

1260178-67-3

1260772-91-5

1263363-54-7

571188-81-3

147687-17-0

93076-03-0

58837-31-3

5418-94-0

944902-03-8

76360-94-6

893444-14-9

893444-46-7

17481-62-8

175358-02-8

887582-84-5

1311254-72-4

16054-93-6

259809-78-4

260273-82-3

900156-22-1

181525-38-2

897359-74-9

62459-02-3

175357-98-9

1250998-81-2

1956328-12-3

1956332-32-3

882670-91-9

118726-21-9

582334-02-9

582334-04-1

1499166-63-0

1029720-84-0

902576-09-4

171178-48-6

882679-26-7

1289187-97-8

1098340-26-1

582334-06-3

1256353-15-7

1665288-67-4

171179-06-9

1956321-99-5

552331-43-8

62259-92-1

84341-13-9

917757-12-1

1333382-30-1

148191-54-2

148191-55-3

180904-95-4

1210610-70-0

1210768-40-3

1306738-31-7

87591-84-2

32092-27-6

87591-74-0

162469-86-5

1256643-38-5