Product Name:1-[2-(diethoxymethyl)-1H-indol-6-yl]methanamine

IUPAC Name:1-[2-(diethoxymethyl)-1H-indol-6-yl]methanamine

Molecular Formula:C14H20N2O2
Catalog Number:CM1046366
Molecular Weight:248.33

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Product Details

CAS NO:2648259-11-2
Molecular Formula:C14H20N2O2
Melting Point:-
Smiles Code:CCOC(OCC)C1=CC2=C(N1)C=C(CN)C=C2
Catalog Number:CM1046366
Molecular Weight:248.33
Boiling Point:

Category Infos

Indole is a compound of pyrrole and benzene in parallel, also known as benzopyrrole. There are two combinations of pyrrole and benzene, called indole and isoindole, respectively. Many derivatives of indole have physiological and pharmacological activities, and can synthesize vasodilators, antihistamines, antipyretic analgesics, etc. in medicine, so indole is also a very important heterocyclic compound.
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STORM's lead clinical program STC-15 is a first-in-class inhibitor of RNA modification and is the first ever RNA methyltransferase inhibitor to enter clinical development. STC-15 is an oral small molecule that inhibits METTL3, an RNA methyltransferase implicated in oncology and other diseases. Certain RNA methyltransferases are important regulators of RNA sensing and innate immune activation and represent novel immune-regulatory targets. STC-15 has also been shown preclinically to inhibit tumour growth through mechanisms involving anti-cancer immune responses, such as changes in interferon signalling and synergy with T cell checkpoint blockade. STORM commenced the dosing of the first patient in a Phase 1 clinical study of STC-15 in patients living with solid tumours in November 2022 and anticipates presenting first results from its study in 2024.
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