Product Name:Methyl 4-oxo-4H-pyrido[1,2-a]pyrimidine-2-carboxylate

IUPAC Name:methyl 4-oxo-4H-pyrido[1,2-a]pyrimidine-2-carboxylate

Molecular Formula:C10H8N2O3
Catalog Number:CM575328
Molecular Weight:204.19

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Product Details

CAS NO:23951-66-8
Molecular Formula:C10H8N2O3
Melting Point:-
Smiles Code:COC(=O)C1=CC(=O)N2C=CC=CC2=N1
Catalog Number:CM575328
Molecular Weight:204.19
Boiling Point:
MDL No:MFCD30471382

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STORM's lead clinical program STC-15 is a first-in-class inhibitor of RNA modification and is the first ever RNA methyltransferase inhibitor to enter clinical development. STC-15 is an oral small molecule that inhibits METTL3, an RNA methyltransferase implicated in oncology and other diseases. Certain RNA methyltransferases are important regulators of RNA sensing and innate immune activation and represent novel immune-regulatory targets. STC-15 has also been shown preclinically to inhibit tumour growth through mechanisms involving anti-cancer immune responses, such as changes in interferon signalling and synergy with T cell checkpoint blockade. STORM commenced the dosing of the first patient in a Phase 1 clinical study of STC-15 in patients living with solid tumours in November 2022 and anticipates presenting first results from its study in 2024.
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