cas 2105905-46-0|| where to buy 4,6-dichloro-1H-pyrazolo[3,4-b]pyridine

Product Name:4,6-dichloro-1H-pyrazolo[3,4-b]pyridine

IUPAC Name:4,6-dichloro-1H-pyrazolo[3,4-b]pyridine

CAS:2105905-46-0
Molecular Formula:C6H3Cl2N3
Purity:95%+
Catalog Number:CM325579
Molecular Weight:188.01

Packing Unit Available Stock Price($) Quantity
CM325579-1g in stock --
CM325579-5g in stock --

For R&D use only.

Inquiry Form

   refresh    

Product Details

CAS NO:2105905-46-0
Molecular Formula:C6H3Cl2N3
Melting Point:-
Smiles Code:ClC1=CC(Cl)=C2C(NN=C2)=N1
Density:
Catalog Number:CM325579
Molecular Weight:188.01
Boiling Point:
MDL No:
Storage:Keep in a tight container and store at 2°C~8°C for long term and which can be kept in a tight container at ambient temperature f

Category Infos

Pyrazolopyridines
Over the past few years, many pyrazole fused-ring systems, especially with applications in medicinal chemistry, have been published. These include general structures such as pyrazoline, pyrazoline, pyrazoquinoline, pyrazoloisoquinoline, pyrazoline, pyrazolopyrazine, pyrazolopyrazine, pyranopyrazole, pyrano Pyrazoles, pyrazolotriazines and pyrazole fused phosphorus rings.

Column Infos

Quemliclustat
Data from a phase 1b study of Quemliclustat-based regimens showed promising overall survival in treatment-naïve metastatic pancreatic cancer. Median Overall Survival was 15.7 months for all patients treated with 100 mg quemliclustat-based regimens in the ARC-8 study, which exceeds the historical benchmark data for chemotherapy alone.
Quemliclustat is an investigational, potent and selective small molecule CD73 inhibitor. CD73 is the primary enzymatic producer of immunosuppressive adenosine in the tumor microenvironment, and high CD73 expression is associated with significantly poorer prognosis in several tumor types. Quemliclustat has been shown to block the production of adenosine. Once the immunosuppressive effects of adenosine are removed, activation of antitumor immune cells may be restored, resulting in cancer cell death.