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Product Name:((2R,7aS)-2-Fluorohexahydro-1H-pyrrolizin-7a-yl)methanol

IUPAC Name:[(2R,7aS)-2-fluoro-hexahydro-1H-pyrrolizin-7a-yl]methanol

: CAS：2097518-76-6; Molecular Formula：C8H14FNO; Purity：98%

: Catalog Number：CM336250; Molecular Weight：159.20

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Product Details

: CAS NO:2097518-76-6; Molecular Formula:C8H14FNO; Melting Point:-; Smiles Code:OC[C@@]12CCCN1C[C@H](F)C2; Density:

: Catalog Number:CM336250; Molecular Weight:159.20; Boiling Point:; MDL No:; Storage:Keep in a tight container and store at 2°C~8°

Category Infos

: Pyrrolidines; Pyrrolidine, also known as tetrahydropyrrole, is a saturated five-membered heterocyclic ring, which is miscible with water. Pyrrolidine exists in many alkaloids and drug molecules, such as kappa opioids, antagonists of dopamine D4 receptors, and HIV reverse transcriptase inhibitors.

: Pyrrolizines; Pyrrolizine derivatives are a class of heterocyclic compounds that can be used as scaffolds for anticancer drugs. The unique antitumor properties of mitomycin C have prompted chemists to develop different pyrrolizine systems and evaluate their potential antitumor activity against a variety of cancers.

Column Infos

: HRS-4642; HRS-4642 is a high affinity, selective, long-acting, and non-covalent KRAS G12D inhibitor, with an affinity constant of 0.083 nM. HRS-4642 demonstrated robust efficacy against KRAS G12D-mutant cancers both in vitro and in vivo. Importantly, in a phase 1 clinical trial, HRS-4642 exhibited promising anti-tumor activity in the escalating dosing cohorts. Furthermore, the sensitization and resistance spectrum for HRS-4642 was deciphered through genome-wide CRISPR-Cas9 screening, which unveiled proteasome as a sensitization target. HRS-4642, either as a single agent or in combination with carfilzomib, reshaped the tumor microenvironment toward an immune-permissive one.

Product Other Information

Chemical Compound Information	CAS Number: 2097518-76-6 Chemical Name: ((2R,7aS)-2-Fluorohexahydro-1H-pyrrolizin-7a-yl)methanol Molecular Formula: C8H14FNO
Description	((2R,7aS)-2-Fluorohexahydro-1H-pyrrolizin-7a-yl)methanol is an organic compound with the chemical formula C8H14FNO and the CAS number 2097518-76-6. It belongs to the class of compounds known as pyrrolizidines, which are saturated aza-heterocycles derived from pyrrolidine through a ketene shift. This compound contains a pyrrolizidine ring system substituted with a fluorine atom and a hydroxymethyl group.
Product Properties	((2R,7aS)-2-Fluorohexahydro-1H-pyrrolizin-7a-yl)methanol is an organic compound characterized by its pyrrolizidine ring structure with a fluorine atom and a hydroxymethyl group substitution. It belongs to the pyrrolizidine class of compounds and has the molecular formula C8H14FNO.
Product Applications	The compound's specific applications might be context-dependent and could be related to its unique chemical structure. It could potentially be used in research settings, pharmaceutical synthesis, or as a precursor in the creation of other organic compounds.
Precautions	Safety: Handle this compound with appropriate safety measures, including the use of personal protective equipment (PPE) such as gloves, lab coat, and safety goggles. Storage: Store in a cool, dry, well-ventilated area away from direct sunlight, heat, and incompatible materials. Handling: Avoid inhalation, ingestion, and skin contact. Work in a fume hood or well-ventilated area when handling. Disposal: Follow proper disposal guidelines for hazardous chemical waste as per local regulations.