Pyridine is a six-membered heterocyclic compound containing one nitrogen heteroatom. Pyridine and piperidine are the most frequently occurring heterocyclic building blocks in drug molecules. According to incomplete statistics, there are currently more than 180 drugs containing pyridine or piperidine structure that have been marketed, nearly 1/5 of the drugs approved for marketing in recent years contain these two structures.
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Pyridine is a basic heterocyclic organic compound with the chemical formula C5H5N. It is structurally related to benzene, with one methine group (=CH−) replaced by a nitrogen atom. It is a highly flammable, weakly alkaline, water-miscible liquid with a distinctive, unpleasant fish-like smell.
Organic light emitting diodes (devices) or OLEDs are monolithic solid-state devices that typically consist of a series of organic thin films sandwiched between two thin film conductive electrodes. It is a display technology used in many electronic devices, such as smartphones, televisions, and wearables. In an OLED display, each pixel is made up of organic compounds that emit light when an electric current passes through them. Unlike traditional LCD displays, this eliminates the need for a backlight. As a result, OLED displays can achieve deeper blacks and higher contrast ratios, leading to vibrant and more realistic images.
Erasca's Naporafenib receives FDA Fast Track Designation in combination with Trametinib (Mekinist) for the treatment of adult patients with advanced NRAS-mutated melanoma. Naporafenib has been dosed in over 500 patients to date, and has demonstrated preliminary evidence of its effectiveness. Naporafenib (LXH254) is an orally available pan-RAF inhibitor under development. It targets downstream BRAF and CRAF nodes, and has first-in-class and best-in-class potential in NRAS-mutated melanoma and other RAS/MAPK pathway-altered solid tumors.