Thiazoles are very important functional groups in medicinal chemistry. They act as ligands on a variety of biological matrices. Thiazoles are used in a wide range of therapeutic applications, such as antibacterial, antiretroviral, antifungal, antiallergic, antihypertensive, pain treatment, and to control symptoms of schizophrenia.
Tovorafenib is a highly selective, brain-penetrating pan-RAF kinase inhibitor designed to target key enzymes in the MAPK signaling pathway. Tovorafenib has been granted Breakthrough Therapy Designation by the U.S. FDA for the treatment of pediatric patients with low-grade gliomas harboring RAF mutations. The hope is to bring this therapy soon to children in need of new treatment options.