Piperidine is an azacycloalkane that is cyclohexane in which one of the carbons is replaced by a nitrogen. Although piperidine is a common organic compound, it is an immensely important class of compounds medicinally: the piperidine ring is the most common heterocyclic subunit among FDA approved drugs.
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The novel medication for the treatment of adults with major depressive disorder (MDD), Gepirone has eventually been approved by the FDA in late September following a long quest. Geprione belongs to the azapirone group, as the same class as buspirone. Gepirone acts as a full agonist at serotonin 5-HT1A autoreceptors and is generally, a partial agonist at postsynaptic serotonin 5-HT1A receptors. Gepirone has a unique antidepressant effect that relieves depressive symptoms without significant side effects.