Syndax announced pivotal AUGMENT-101 trial of Revumenib in relapsed/refractory KMT2Ar acute leukemia met primary endpoint and stopped early for efficacy following protocol-defined interim analysis. Revumenib is a potent, selective, small molecule inhibitor of the menin-KMT2A binding interaction that is being developed for the treatment of KMT2A-rearranged, also known as mixed lineage leukemia rearranged or MLLr, acute leukemias including ALL and AML, and NPM1-mutant AML.
Chemenu has been working to develop more compounds for drug discovery. Here are the building blocks we can provide.