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ABBV-712

TYK2 is an attractive target for various autoimmune diseases as it regulates signal transduction downstream of IL-23 and IL-12 receptors. Selective TYK2 inhibition offers a differentiated clinical profile compared to currently approved JAK inhibitors. Scientists discovered the clinical candidate ABBV-712 in the optimization of selective TYK2 inhibitors targeting the pseudokinase domain.

(But-3-yn-1-yloxy)(tert-butyl)dimethylsilane
(But-3-yn-1-yloxy)(tert-butyl)dimethylsilane
CM137865
78592-82-2
tert-butyldimethyl{[3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)but-3-en-1-yl]oxy}silane
tert-butyldimethyl{[3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)but-3-en-1-yl]oxy}silane
CM1047285
251928-73-1
Methyl 2,6-dichloroisonicotinate
Methyl 2,6-dichloroisonicotinate
CM178131
42521-09-5
4-Pyridinemethanol,2,6-dichloro-
4-Pyridinemethanol,2,6-dichloro-
CM101492
101990-69-6
Pyridine, 2,6-dichloro-4-(methoxymethyl)-
Pyridine, 2,6-dichloro-4-(methoxymethyl)-
CM653318
221093-39-6
N-{3-bromo-1H-pyrrolo[2,3-c]pyridin-5-yl}acetamide
N-{3-bromo-1H-pyrrolo[2,3-c]pyridin-5-yl}acetamide
CM1047286
2368945-96-2
tert-butyl 5-acetamido-3-bromo-pyrrolo[2,3-c]pyridine-1-carboxylate
tert-butyl 5-acetamido-3-bromo-pyrrolo[2,3-c]pyridine-1-carboxylate
CM429663
2368945-95-1
(2R)-2-[6-chloro-4-(methoxymethyl)pyridin-2-yl]butane-1,2,4-triol
(2R)-2-[6-chloro-4-(methoxymethyl)pyridin-2-yl]butane-1,2,4-triol
CM1047288
(3R)-3-[6-chloro-4-(methoxymethyl)pyridin-2-yl]oxolan-3-ol
(3R)-3-[6-chloro-4-(methoxymethyl)pyridin-2-yl]oxolan-3-ol
CM1047289
3-[6-chloro-4-(methoxymethyl)pyridin-2-yl]but-3-en-1-ol
3-[6-chloro-4-(methoxymethyl)pyridin-2-yl]but-3-en-1-ol
CM1047287